:root{--fg: #0b1720;--fg-soft: #324250;--muted: #6b7a88;--bg: #ffffff;--surface: #f6f8fa;--surface-2: #eef2f5;--border: #dde3e8;--accent: #1a73e8;--accent-soft: #e8f0fe;--card-shadow: 0 1px 2px rgba(16, 24, 40, .04), 0 1px 3px rgba(16, 24, 40, .05)}*{box-sizing:border-box}html,body{margin:0;padding:0}body{font-family:Inter,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,sans-serif;color:var(--fg);background:var(--bg);font-size:20px;line-height:1.55;-webkit-font-smoothing:antialiased}a{color:var(--accent);text-decoration:none}a:hover{text-decoration:underline}header.site{border-bottom:1px solid var(--border);padding:1.1rem 2rem;display:flex;gap:1.75rem;align-items:center;background:var(--bg);position:sticky;top:0;z-index:10}header.site .brand{font-weight:700;font-size:1.3rem;color:var(--fg);letter-spacing:-.01em;display:inline-flex;align-items:baseline;gap:.6rem}header.site .brand-sub{font-weight:500;font-size:.92rem;color:var(--muted);letter-spacing:0}header.site .nav{display:flex;gap:1.5rem;font-size:1.05rem}header.site .nav a{color:var(--fg-soft)}header.site .nav a:hover{color:var(--accent);text-decoration:none}header.site .header-search{position:relative;margin-left:auto}header.site .header-search input{width:380px;padding:.6rem .95rem;border:1px solid var(--border);border-radius:8px;font:inherit;font-size:1.02rem;background:var(--surface);color:var(--fg);outline:none;transition:border-color .15s,box-shadow .15s,background .15s}header.site .header-search input:focus{border-color:var(--accent);background:var(--bg);box-shadow:0 0 0 3px var(--accent-soft)}header.site .header-search ul{position:absolute;top:calc(100% + 4px);right:0;left:0;list-style:none;padding:.25rem;margin:0;background:var(--bg);border:1px solid var(--border);border-radius:6px;box-shadow:0 6px 18px #00000014;max-height:340px;overflow-y:auto;z-index:20}header.site .header-search ul li a{display:flex;gap:.7rem;align-items:baseline;padding:.4rem .6rem;border-radius:4px;color:var(--fg);text-decoration:none}header.site .header-search ul li a:hover{background:var(--surface);text-decoration:none}header.site .header-search .r-gene{font-weight:600;font-size:.95rem}header.site .header-search .r-uid{font-family:JetBrains Mono,monospace;font-size:.85rem;color:var(--muted)}main{padding:1.75rem 2rem 3rem;max-width:min(1920px,calc(100vw - 3rem));margin:0 auto}footer.site{border-top:1px solid var(--border);padding:2rem;background:var(--surface);margin-top:3rem;font-size:.92rem}footer.site .foot-inner{display:grid;grid-template-columns:repeat(3,1fr);gap:2rem;max-width:1720px;margin:0 auto}footer.site a{color:var(--fg-soft)}footer.site a:hover{color:var(--accent)}@media(max-width:720px){footer.site .foot-inner{grid-template-columns:1fr}}h1{margin:0;font-size:2rem;font-weight:700;letter-spacing:-.015em}h2{margin:0 0 .75rem;font-size:1.2rem;font-weight:600;letter-spacing:-.005em;color:var(--fg)}h3{margin:0 0 .5rem;font-size:.95rem;font-weight:600;color:var(--fg-soft);text-transform:uppercase;letter-spacing:.04em}.muted{color:var(--muted)}.chip{display:inline-block;padding:.15rem .55rem;background:var(--surface-2);border-radius:999px;font-size:.78rem;color:var(--fg-soft);font-weight:500}.card{background:var(--bg);border:1px solid var(--border);border-radius:8px;padding:1.25rem 1.4rem;margin-bottom:1.25rem;box-shadow:var(--card-shadow)}.card-header{display:flex;justify-content:space-between;align-items:center;gap:1rem;margin-bottom:.9rem;flex-wrap:wrap}.controls{display:flex;gap:1rem;flex-wrap:wrap;font-size:.88rem;align-items:center}.controls label{display:inline-flex;gap:.45rem;align-items:center;color:var(--fg-soft)}.controls select,.controls input[type=text]{font:inherit;font-size:.88rem;padding:.25rem .5rem;border:1px solid var(--border);border-radius:4px;background:var(--bg);color:var(--fg)}.controls input[type=checkbox]{accent-color:var(--accent)}.btn{font:inherit;font-size:.84rem;font-weight:500;padding:.35rem .8rem;border:1px solid var(--border);border-radius:4px;background:var(--bg);color:var(--fg);cursor:pointer;text-decoration:none;display:inline-block}.btn:hover{background:var(--surface);text-decoration:none}.btn.primary{background:var(--accent);color:#fff;border-color:var(--accent)}.btn.primary:hover{background:#1557b5}code,pre{font-family:JetBrains Mono,ui-monospace,SFMono-Regular,Menlo,monospace}pre.seq{font-size:.78rem;line-height:1.5;background:var(--surface);border:1px solid var(--border);border-radius:6px;padding:.85rem 1rem;white-space:pre-wrap;word-break:break-all;margin:0}table.clean{border-collapse:collapse;width:100%;font-size:.85rem}table.clean th,table.clean td{padding:.45rem .7rem;text-align:left;border-bottom:1px solid var(--border)}table.clean th{font-weight:500;color:var(--muted);background:var(--surface)}