HSA Human Sheddome Atlas
UniProt · Membrane protein

EGFR (Epidermal Growth Factor Receptor)

P00533 · 1210 aa ·Signal peptide ·1× TM · 6 predicted cleavages ·18 experimental cleavages

Cleavage peaks

Structure

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AlphaFold · pLDDT

Experimental cleavages

15 unique positions · 18 annotations · 2/15 (13%) covered by peaks
Sources (filter in the plot above): meropsuniprotschaeffer22
P1 pos Sources Proteases References
24 meropsuniprot XS26.001 , Signal peptidase 15340161 6328312
356 merops M35.004
500 schaeffer22 36313163
679 merops CAPN2 26796116
683 merops CAPN1 , CAPN2 26796116
684 merops CAPN2 26796116
685 merops CAPN1 , CAPN2 26796116
733 merops CAPN2 8055914
1006 merops CASP3 11226410
1009 merops CASP3 11226410
1030 merops CAPN2 8055914
1059 merops CAPN2 8055914
1086 merops CAPN2 8055914
1151 merops CAPN2 8055914
1185 merops CAPN2 8055914

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Sequence

1210 aa
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