The Human Sheddome Atlas
Predicted ectodomains, topology, and domain structure across the human membrane proteome — integrated with experimental cleavage evidence.
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5,211
Proteins →
in atlas
2,871
Sheddome proteins →
55% of atlas, ≥1 predicted cleavage
26,838
Predicted ectodomains →
11,371 contain ≥1 intact domain
8,246
Predicted cleavages →
~2.9 per shedding protein
109
Distinct proteases →
from 2,754 experimental sites
Compare protein families
Explore families → Explore aligned cleavage predictions, domains, and evidence across related proteins.