HSA Human Sheddome Atlas
UniProt · Membrane protein

ADAM10 (Disintegrin and Metalloproteinase Domain-Containing Protein 10)

O14672 · 748 aa ·Signal peptide ·Propeptide ·1× TM · 8 predicted cleavages ·22 experimental cleavages

Cleavage peaks

Structure

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AlphaFold · pLDDT

Experimental cleavages

11 unique positions · 22 annotations · 10/11 (91%) covered by peaks
Sources (filter in the plot above): topfindschaeffer22weeks21uniprotmerops
P1 pos Sources Proteases References
18 topfindschaeffer22weeks21 23264352 36313163 33526672
19 uniprot Signal peptidase
77 schaeffer22 36313163
109 merops MEP1B 21693781
213 meropsschaeffer22uniprot FURIN , PCSK2 , PCSK4 , PCSK6 , PCSK5 , PCSK7 , furin and PCSK7 11481247 18505722 36313163
215 topfind 23264352
331 schaeffer22weeks21 36313163 33526672
378 schaeffer22 36313163
387 schaeffer22 36313163
420 schaeffer22 36313163
646 schaeffer22 36313163

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Full JSON

Sequence

748 aa
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