UniProt · Membrane protein

TNF (Tumor Necrosis Factor)

P01375 · 233 aa ·1× TM · 2 predicted cleavages ·32 experimental cleavages

Cleavage peaks

Domain source Stringency Domain labels Peak lines Peak labels

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Colour: Topology pLDDT

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AlphaFold · pLDDT

17 unique positions · 32 annotations · 9/17 (53%) covered by peaks

Sources (filter in the plot above): meropsuniprotmerops+pmaphprdpmap

P1 pos	Sources	Proteases	References
`49`	meropsuniprot	SPPL2A , SPPL2B , SPPL2A or SPPL2B	19189970 16829951
`50`	uniprot	C-domain 1	—
`51`	meropsuniprot	SPPL2A , SPPL2B , SPPL2A or SPPL2B	19189970 16829951
`52`	uniprot	C-domain 2	—
`69`	merops+pmap	MMP14	15118097
`72`	merops+pmap	MMP14	15118097
`74`	hprdmeropsmerops+pmap	MMP14 , ADAM8	9920899 10799478 15118097 12135759
`75`	merops	MMP17	12135759
`76`	hprdmeropspmapuniprot	ADAM17 , MMP14 , ADAM8 , ADAM10	9920899 10799478 12135369 15118097 12135759 9305925 9034190
`77`	uniprot	Tumor necrosis factor, soluble form	3856324
`78`	meropsmerops+pmap	ADAM19 , C25.001	12682046 9506956
`79`	hprdmeropsmerops+pmap	ADAM19 , ADAM9	9920899 12682046 12135759
`82`	merops+pmap	C25.001	9506956
`108`	merops+pmap	C25.003	9506956
`141`	merops+pmap	C25.002	9506956
`166`	merops+pmap	C25.002	9506956
`174`	merops+pmap	C25.002	9506956

233 aa

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