HSA Human Sheddome Atlas
UniProt · Membrane protein

APP (Amyloid-Beta Precursor Protein)

P05067 · 770 aa ·Signal peptide ·1× TM · 1 predicted cleavages ·170 experimental cleavages

Cleavage peaks

Structure

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AlphaFold · pLDDT

Experimental cleavages

59 unique positions · 170 annotations · 19/59 (32%) covered by peaks
Sources (filter in the plot above): ascentmerops+uniprotpaperschaeffer22weeks21meropsuniprothprd+meropshprd
P1 pos Sources Proteases References
17 ascentmerops+uniprotpaperschaeffer22weeks21 XS26.001 33536314 12665801 2900137 3597385 33796845 36313163 33526672
124 merops MEP1A , MEP1B 21693781
197 uniprot caspases 10319819
219 uniprot caspases 10319819
229 merops A02.001 1907279
286 uniprot N-APP
295 paper 33796845
301 merops PRSS3 19920152
338 paper 33796845
380 merops MEP1B 21693781
386 paper 33796845
396 merops C47.003 15255185
399 merops C47.003 15255185
429 ascentweeks21 33536314 33526672
463 merops MMP16 16567416
579 meropspaper MMP14 , MMP16 12767235 16567416 33796845
580 paper 33796845
608 paper 33796845
609 merops HTRA2 16968707
610 merops A02.001 1907279
611 paper 33796845
622 merops MMP16 16567416
624 weeks21 33526672
627 meropsweeks21 CTSD 8943232 33526672
668 hprd+merops CTSD 8943232
670 merops KLK6 , S9G.058 12878203 8142398
671 meropsuniprot BACE1 , BACE2 , S9G.058 , Soluble APP-beta , beta-secretase 10677483 12423367 8142398 11851430
672 hprd+meropsmeropsuniprot CASP6 , BACE2 , HTRA1 , U9G.071 , caspase-6; when associated with variant 670-N-L-671 10438520 12423367 15855271 18682830
673 merops CTSD 8943232
674 hprd+meropsmerops CTSD , BACE2 , MME , ECE1 , IDE , U9G.071 8943232 12423367 16787929 18682830
675 merops CTSD , IDE , S01.243 8943232 16787929 10635572
676 merops BACE2 , ACE , PLG , KLK6 , S01.243 12423367 18085519 10818128 12878203 10635572
678 meropsuniprot U9G.055 , ACE 14741696 11604391 16154999
679 merops S01.422 10635572
681 merops CTSB 9119007
683 merops IDE , HTRA1 18470479 15855271
684 merops BACE2 , IDE , APEH 12423367 16787929 19627603
685 merops BACE2 , CTSB , BLMH , MMP16 , MMP17 , ADAM8 , ADAM9 , ADAM33 , IDE , M9G.026 , APEH 12423367 9119007 16472072 16567416 12135759 14676211 16787929 12128061 19627603
686 merops BACE2 , C04.001 , ADAM10 , IDE , PITRM1 , HTRA1 12423367 21187975 16787929 16849325 15855271
687 meropspaperschaeffer22uniprot A01.035 , BACE2 , CTSB , MMP2 , MMP9 , MMP14 , MMP17 , ADAM10 , ADAM17 , ECE1 , MMEL1 , IDE , PITRM1 , PLG , KLK6 , Soluble APP-alpha , alpha-secretase 10191273 12423367 9119007 7811262 16787929 12135759 12135369 18571334 16849325 10818128 12878203 33796845 36313163 11851430
688 meropspaperschaeffer22 ECE1 , MMEL1 , IDE , M9G.026 16787929 18571334 12128061 33796845 36313163
689 merops BLMH , MME , IDE , S01.422 16472072 16787929 10635572
690 hprd+meropsmeropsuniprot CTSD , CTSE , BACE2 , BLMH , ECE1 , IDE , PITRM1 , M9G.026 , APEH , theta-secretase 10605825 9119007 12065613 16472072 16787929 16849325 12128061 19627603 16816112
691 uniprothprdmerops C80 , CTSD , CTSE , BACE2 , MMP9 , IDE , PITRM1 8943232 10605825 10931940 9119007 16787929 18470479 16849325
693 merops CTSD , CTSB 8943232 9119007
694 merops CTSD , MMP9 8943232 16787929
695 merops S01.422 10635572
698 merops U9G.071 18682830
699 merops IDE , PLG , S01.243 16787929 10818128 10635572
700 merops PITRM1 16849325
701 merops MMP9 , PITRM1 16787929 16849325
703 merops S01.422 10635572
704 merops CTSB , MMP9 , PITRM1 16982417 16787929 16849325
705 hprd+meropsmerops CTSD , MMP2 , MMP9 , PITRM1 , S01.243 10605825 7811262 16787929 19196155 10635572
706 merops MMP2 7811262
707 merops S01.422 10635572
708 meropspaper CTSB 16982417 33796845
709 meropspaper A22.015 , CTSB , PITRM1 20927381 9119007 16849325 33796845
711 meropspaperuniprot PSEN1 , A22.015 , CTSB , ACE , P3(40) , gamma-secretase; site 1 9450754 20927381 16982417 17687040 33796845 11851430

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Sequence

770 aa
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