UniProt · Membrane protein

F2R (Proteinase-Activated Receptor 1)

P25116 · 425 aa ·Signal peptide ·Propeptide ·7× TM · 1 predicted cleavages ·50 experimental cleavages

Cleavage peaks

Domain source Stringency Domain labels Peak lines Peak labels

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Colour: Topology pLDDT

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AlphaFold · pLDDT

23 unique positions · 50 annotations · 10/23 (43%) covered by peaks

Sources (filter in the plot above): uniprothprd+meropshprdmeropsmerops+pmap

P1 pos	Sources	Proteases	References
`21`	uniprot	Signal peptidase	22659187
`25`	hprd+merops	F2	10978167
`32`	hprd+merops	CAPN1	10978167
`36`	hprd+merops	ELANE	10978167
`41`	hprdmeropsmerops+pmapuniprot	MMP1 , GZMB , KLK5 , KLK14 , ELANE , CTSG , GZMA , S01.151 , KLK1 , PRSS3 , F10 , F2 , PROC , PLG , KLK6 , TPSB2 , thrombin and CTSG	10644723 10978167 15707890 8947506 16885167 17623652 9020112 1672265 7744748
`42`	merops+pmap	KLK6	16885167
`43`	hprd+meropsmeropsmerops+pmap	CTSG , S01.001 , KLK5	10978167 8947506 16885167
`44`	merops	CTSG	15371558
`45`	merops+pmap	KLK6	16885167
`46`	meropsmerops+pmap	S01.001 , KLK14 , KLK6 , TPSB2	8947506 16885167 9020112
`47`	hprd	—	10978167
`48`	hprd+merops	PRTN3	10978167
`51`	merops+pmap	TPSB2	9020112
`54`	hprd+merops	PRTN3	10978167
`55`	hprd+meropsuniprot	CTSG	10978167 7744748
`69`	hprd+merops	CTSG	10978167
`70`	hprd+merops	PLG	10978167
`72`	hprd+merops	ELANE	10978167
`74`	merops	ELANE	9058715
`76`	hprd+merops	CAPN1	10978167
`82`	hprd+meropsmerops	S01.151 , PLG	10978167 15371558
`86`	hprd+merops	ELANE	10978167
`92`	hprd+merops	PRTN3	10978167

425 aa

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