UniProt · Membrane protein

NOTCH1 (Neurogenic Locus Notch Homolog Protein 1)

P46531 · 2555 aa ·Signal peptide ·1× TM · 6 predicted cleavages ·13 experimental cleavages

Cleavage peaks

Domain source Stringency Domain labels Peak lines Peak labels

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Colour: Topology pLDDT

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AlphaFold · pLDDT

5 unique positions · 13 annotations · 5/5 (100%) covered by peaks

Sources (filter in the plot above): uniprothprdmeropsschaeffer22

P1 pos	Sources	Proteases	References
`18`	uniprot	Signal peptidase	—
`1664`	hprdmeropsschaeffer22uniprot	PCSK2 , PCSK4 , PCSK6 , PCSK5 , PCSK7 , furin-like protease	9653148 18505722 36313163
`1710`	uniprot	ADAM17	—
`1720`	hprd	—	10882063 11518718
`1721`	uniprot	Notch 1 extracellular truncation	—

2555 aa

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