HSA Human Sheddome Atlas
UniProt · Membrane protein

F2RL1 (Proteinase-Activated Receptor 2)

P55085 · 397 aa ·Signal peptide ·Propeptide ·7× TM · 1 predicted cleavages ·44 experimental cleavages

Cleavage peaks

Structure

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AlphaFold · pLDDT

Experimental cleavages

26 unique positions · 44 annotations · 12/26 (46%) covered by peaks
Sources (filter in the plot above): uniprotmerops+pmaphprd+merops+pmapmeropshprd+merops
P1 pos Sources Proteases References
25 uniprot Signal peptidase
31 merops+pmap KLK5 16885167
34 hprd+merops+pmapmerops PLG , PRTN3 10978167 12370398
36 hprd+meropsmeropsmerops+pmapuniprot TPSB2 , C01.072 , KLK14 , PRTN3 , F2 , PLG , KLK6 , KLK4 , ST14 , PRSS1 , trypsin , Removed for receptor activation 9020112 19621073 16885167 12370398 10978167 15389820 17131055 8615752
37 merops M04.005 15705968
38 uniprothprd+merops Proteinase-activated receptor 2, alternate cleaved 1 , CTSG 10978167
39 uniprot Proteinase-activated receptor 2, alternate cleaved 2
41 meropsmerops+pmap KLK14 , PRTN3 , S01.151 , KLK6 , TPSB2 16885167 12370398 9020112
42 hprd+merops ELANE 10978167
45 hprd+merops CAPN2 10978167
48 hprd+merops+pmap ELANE 10978167
51 hprd+meropsmerops+pmap S01.151 , KLK14 10978167 16885167
52 merops M04.005 15705968
53 hprd+merops ELANE 10978167
55 hprd+merops PRTN3 10978167
57 hprd+merops PRTN3 10978167
58 hprd+merops CAPN2 10978167
59 hprd+merops+pmap CAPN1 10978167
61 hprd+merops PRTN3 10978167
62 hprd+merops PRTN3 10978167
64 hprd+merops+pmap CTSG 10978167
71 hprd+merops CAPN2 10978167
72 hprd+merops PRTN3 10978167
74 hprd+merops+pmap ELANE 10978167
75 hprd+merops+pmap PRTN3 10978167
76 hprd+merops+pmap ELANE 10978167

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Sequence

397 aa
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